Two parallel reports in Nature Biotechnology describe new single-strand deaminase platforms that expand programmable RNA editing. One study introduces a single-strand deaminase–assisted system that rewrites multiple bases within single transcripts, enabling multiplexed RNA edits without altering DNA. The other details an AIM (Adjustable RNA Information Manipulation) architecture that delivers precise, tunable RNA base changes. Both groups validated editing in cell models and demonstrated control over edit scope and specificity, positioning RNA editing as a transient, potentially safer alternative to permanent DNA changes. The technologies are poised to accelerate therapeutic concepts that require reversible modulation of transcripts, such as tuning oncogene expression or transiently altering splicing in genetic disease.