Two complementary papers in Nature Biotechnology unveiled single‑strand deaminase platforms that enable programmable, multi‑base editing of RNA transcripts. One report describes a deaminase-assisted system that can rewrite multiple bases within a single RNA molecule in vivo, expanding the scope of transient transcript modulation. The authors demonstrated multiplexed base changes in target RNAs and validated functional effects in cell models. A separate study introduces an adjustable RNA editing platform—AIM—that provides tighter control over editing site selection and efficiency, enabling clinicians and researchers to fine‑tune edits on demand. Both teams emphasized transient targeting of RNA as an alternative to permanent DNA edits, positioning these tools for indications where temporary modulation of gene expression or protein isoforms is preferable. Clarification: RNA editing alters transcript sequences transiently and does not change the underlying genomic DNA, lowering long‑term mutation risk compared with DNA editing.