Two independent reports describe single‑strand deaminase platforms that enable programmable and multiplexed RNA editing across transcripts. One study presents an adjustable RNA information manipulation (AIM) approach that achieves controllable, site‑specific RNA edits; a companion Nature Biotechnology paper details a single‑strand deaminase‑assisted system for simultaneous multi‑base rewrites within a single RNA transcript. Both teams demonstrated efficient rewriting of target bases in cellular models and provided validation data indicating improved precision and payload flexibility versus existing RNA editors. RNA editing modifies transcript sequences transiently without altering genomic DNA; this property is attractive for therapeutic applications where reversible modulation of protein expression is preferred. The work advances toolkit options for RNA‑targeting therapies and for functional studies of disease‑linked RNAs.