A single‑strand deaminase‑assisted RNA editing platform was published in Nature Biotechnology, describing a system that can simultaneously rewrite multiple bases within single RNA transcripts. The platform leverages a programmable deaminase to install precise A→I and C→U changes across transcripts and demonstrates activity in mammalian cells and disease‑relevant models. The paper presents engineering of deaminase variants and delivery modalities that improve editing window control and reduce collateral RNA damage. Authors validated functional outcomes on transcripts tied to disease phenotypes, showing modulation of protein expression and downstream cellular responses. The approach expands RNA therapeutics by enabling multibase correction without permanent DNA modification.