A Nature Biotechnology study details a single‑strand deaminase‑assisted RNA editing platform that rewrites multiple bases within single RNA transcripts. The authors present a modular system that achieves multiplexed, programmable RNA edits in cells, expanding functional RNA manipulation beyond single‑site edits. The paper reports biochemical characterization, specificity profiling and proof‑of‑concept functional modulation in cellular models. For therapeutic RNA programs, the platform offers an alternative to DNA editing with transient effects and potentially lower genomic risk; authors note remaining work on delivery, durability and transcriptome‑wide specificity.