A multi‑center single‑cell RNA‑sequencing pan‑cancer study identified expression‑based cancer cell clusters specific to bone metastases and highlighted potentially targetable features of the metastatic microenvironment. Investigators used single‑cell profiling to separate tumor subpopulations and stromal interactions that correlate with bone tropism and therapy resistance. The dataset points to candidate pathways and cell states that may underlie metastatic colonization of bone and suggests microenvironmental targets for drug development. Authors emphasized the translational value of single‑cell resolution in revealing heterogeneity that bulk profiling misses and recommended follow‑up functional validation and target prioritization for clinical translation.