Single-cell RNA sequencing (scRNA-seq) has matured into a cornerstone technology enabling detailed cellular analysis across tissues. The International Human Cell Atlas (HCA) Consortium is near completion of healthy tissue atlases and is now expanding into spatial atlas building and disease inclusion. Concurrently, Ultima Genomics provides affordable sequencing support fueling large-scale experiments. Industry leaders note the convergence of affordable sequencing, single-cell resolution, and AI as transformative for uncovering cellular complexity and driving biotech innovation.