A Pediatric Research study identified serum immune biomarkers that correlate with severity and clinical recovery in multisystem inflammatory syndrome in children (MIS‑C). Investigators measured inflammatory mediators longitudinally and linked patterns to organ involvement, disease trajectory, and convalescence. The panel could help stratify MIS‑C patients for immunomodulatory therapy and guide discharge planning. The work emphasizes biomarker‑guided care in pediatric hyperinflammation and supports efforts to standardize outcome measures for post‑COVID inflammatory syndromes.