A Pediatric Research study by Wolff and Koutroulis identified serum immune biomarkers that track severity and recovery in Multisystem Inflammatory Syndrome in Children (MIS‑C). The paper delineates inflammatory pathways and longitudinal biomarker trajectories linked to clinical course and organ dysfunction. Authors propose candidate markers for risk stratification and for monitoring resolution after therapy, offering clinicians measurable endpoints to guide treatment intensity. The findings may inform clinical trial endpoints and biomarker panels for pediatric hyperinflammatory disorders.