Two studies advance the clinical and mechanistic understanding of sepsis. A multicenter analysis led by Hu et al. found serum IgG levels predict sepsis outcomes and may identify patients who benefit from adjunctive immunoglobulin therapy, proposing stratified treatment approaches. Separately, investigators highlighted ferroptosis as a key driver in sepsis pathophysiology, linking iron-dependent lipid peroxidation to organ dysfunction and inflammatory amplification. Ferroptosis is a regulated, iron-catalyzed cell death pathway distinct from apoptosis; together these reports suggest combining immune-supportive interventions with ferroptosis-targeted agents could be a rational therapeutic axis to test in sepsis trials.