Two independent studies converge on actionable sepsis biology. First, researchers delineated ferroptosis — an iron‑dependent form of regulated cell death — as a contributing mechanism in sepsis pathogenesis, linking lipid peroxidation and immune dysregulation to organ injury. Second, Hu et al. show that baseline serum IgG levels stratify sepsis outcomes and predict response to specific treatments. Together the reports provide both a mechanistic target (ferroptosis pathways) and a measurable biomarker (IgG) that could guide patient selection and therapeutic development in septic shock and severe infection trials.