Two complementary studies reframed sepsis pathophysiology and prognostication. One team identified ferroptosis as a central contributor to sepsis development, mapping molecular triggers and cell‑death signatures that amplify inflammation and organ injury. The report points to ferroptosis pathways as candidate therapeutic targets to blunt dysregulated host responses. In parallel, Hu et al. reported that serum immunoglobulin G (IgG) levels predict sepsis outcomes and can identify patients likely to benefit from adjunctive therapies. Together, the mechanistic ferroptosis work and the IgG prognostic data create a translational bridge: biomarkers could help select patients for ferroptosis‑modulating interventions in clinical trials, accelerating precision critical‑care therapeutics.