Nature Biotechnology published a study demonstrating that a host‑defense peptide mimic self‑assembles into delivery micelles that codeliver antifungals, producing potent combinatorial activity with reduced toxicity. The investigators reformulated a clinically relevant antifungal inside peptide micelles and showed synergistic killing in invasive fungal models, with pharmacokinetic and tolerability data from animal studies. The work reports improved tissue delivery to infected sites and lower systemic exposure to free drug, offering a practical formulation strategy to revive or boost existing antifungal agents. Authors position the platform as a modular delivery vehicle for multidrug antifungal regimens and propose translational plans including GLP toxicology and IND‑enabling studies.
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