Nature Biotechnology published paired advances showing self‑assembling peptide and polymer micelles that co‑deliver antifungal drugs and host‑defense mimics to improve efficacy and safety. One paper reports a host‑defense peptide mimic that self‑assembles into delivery micelles and synergizes with conventional antifungals to clear fungal infections in animal models. The formulation boosted potency while lowering systemic toxicity. A second study described peptide‑based micelles engineered to stabilize encapsulated drugs and target fungal tissues, demonstrating improved pharmacokinetics and antifungal activity in preclinical models. Both reports present a delivery‑focused strategy to revive and enhance existing antifungal compounds in the face of rising resistance. Clarification: micelles are nanoscale assemblies that encapsulate hydrophobic drugs, improving solubility, tissue distribution and co‑delivery of combination therapies.