A new workflow introduces low‑cost, scalable sample hashing compatible with single‑cell multiomic platforms, enabling high‑throughput multiplexing of limited clinical specimens. The method builds on Seq‑Well instrumentation and simplifies barcoding while maintaining cellular resolution across transcriptomic, proteomic and epigenetic measurements. By reducing per‑sample costs and increasing multiplex capacity, the approach aims to expand multiomic profiling in translational studies and early‑phase clinical trials. Sample hashing here refers to molecular barcodes that tag cells from distinct samples so they can be pooled and demultiplexed after sequencing.