Researchers at the Institute for Bioengineering of Catalonia and collaborators reported a scalable method to produce thousands of human kidney organoids and successfully integrate them into perfused porcine kidneys during ex vivo machine perfusion, publishing results in Nature Biomedical Engineering. Teams infused human organoids into normothermically perfused pig kidneys to monitor viability and integration in real time. The approach provides a reproducible, high‑throughput pipeline for organoid production and a translational platform to evaluate graft integration and immunologic compatibility. Authors emphasize the potential to use the method for preclinical testing, drug screening, and eventually to create hybrid xenografts or cell‑therapy–augmented organs for transplantation. The work advances organoid scalability and offers a route to bridge laboratory models and preclinical large‑animal evaluation, but it raises regulatory and immunology questions that developers and regulators must address before clinical translation.