Two papers this week advance programmable RNA editing through single-strand deaminases. One Nature Biotechnology report describes a platform that simultaneously rewrites multiple bases within a single RNA transcript, demonstrating multiplexed functional manipulation. A complementary study documents an adjustable single-strand deaminase system that achieves precise, site-selective RNA edits with tunable activity. Both teams validated effects on endogenous transcripts and reported delivery-compatible constructs for cell-based assays. RNA editing changes transcript sequences transiently without altering genomic DNA — an important therapeutic distinction for safety and reversibility.