A citywide rapid whole-genome sequencing (rWGS) program in Dubai reported high diagnostic yield for critically ill infants and toddlers, particularly among cases from consanguineous families. The “Little Falcon” study, led by Ahmad Abou Tayoun and colleagues and published in Nature Medicine, described a coordinated referral and sequencing workflow for 100 children. Investigators sequenced samples on an Illumina NovaSeq 6000 platform at the centralized CAP-accredited genomics center, with clinical molecular geneticists and genetic counselors interpreting variants using ACMG and AMP guidance. The approach emphasized turnaround timing in intensive neonatal and pediatric care. The results add to the evidence base for operationalizing rapid genomics beyond clinical research centers and into system-level delivery models.