The Baker lab released RFdiffusion3 as open source, an all‑atom de novo protein design model that reportedly designs binders for DNA and small molecules and generates catalytic enzymes faster than prior versions. The team published experimental proof‑of‑concept results showing designed proteins that bind specific DNA sequences and complex enzyme catalysts, highlighting broad applications in therapeutics and sustainable chemistry. RFdiffusion3 advances atom‑level control and ten‑fold speed improvements over predecessors, and the authors framed the release as enabling community‑driven innovation across academia and industry.