Researchers from David Baker’s lab released RFdiffusion3 as open‑source software, demonstrating de novo design of proteins that bind DNA and catalyze complex chemistries. The model, described in a bioRxiv preprint, operates at all‑atom resolution and is faster than its predecessor while expanding design scope to nucleic acids and small molecules. Authors reported experimental validation of designed DNA‑binding proteins and enzymes, positioning RFdiffusion3 as a generalizable tool for synthetic biology, therapeutic binder discovery, and enzyme engineering. The Baker lab framed the release as a platform for community innovation across sustainability and medicine. Open sourcing RFdiffusion3 is likely to accelerate applied protein engineering in industry and academia, while raising discussion about stewardship, IP, and downstream translational pathways for designs generated by public models.