Emerging technologies are transforming organ transplantation and tissue engineering. Normothermic regional perfusion (NRP) techniques are improving viability of organs donated after circulatory death. Innovative methods in liver and kidney transplantation optimize graft use and enhance patient outcomes. Researchers successfully engineered functional ureteral tissue from pluripotent stem cells, advancing renal regenerative therapies. Moreover, 3D-printed shape memory polymers offer promising endovascular treatments for intracranial aneurysms. Developments in stem cell-derived extracellular vesicles scaled for clinical use signify strides in scalable regenerative medicine solutions. These advances collectively indicate a surge in personalized and regenerative approaches addressing organ failure and repair.