Researchers at the Spanish National Cancer Research Centre (CNIO), led by Felipe Cortés-Ledesma and Ernesto López de Alba, have comprehensively catalogued approximately 20,000 distinct DNA scar patterns resulting from human double-strand break (DSB) repair mechanisms, termed the human REPAIRome. Published in Science, this resource represents a monumental achievement offering the scientific community an unprecedented tool to understand DNA repair, CRISPR gene editing outcomes, and cancer mutational signatures. The REPAIRome portal facilitates genetic impact assessment on repair processes, with broad applications in basic research and personalized medicine, informing treatment strategies based on DNA repair profiles.