Researchers mined bacterial and archaeal metagenomes to identify retron elements that can be repurposed as self‑priming DNA editors compatible with CRISPR systems. The work validated candidate retrons in experimental assays and outlined engineering paths to improve efficiency and targeting. A complementary patent and technology disclosure described repurposing retrons for correcting large genomic sequences. Retron editors offer an alternative route to template delivery for homology‑directed repair without double‑strand breaks, potentially enabling correction of large or complex genetic lesions. The studies position retrons as emerging tools for gene‑editing toolkits alongside base editors and prime editors, with ongoing optimization required before clinical translation.