The UK Medicines and Healthcare products Regulatory Agency (MHRA) warned that inadequate electronic health record (eHR) systems are causing problems for clinical trial participation by NHS trusts. The regulator said noncompliant systems could lead sponsors to reject sites during site selection and may also jeopardize later marketing authorization applications or journal publications if trial data cannot be reconstructed. MHRA’s guidance clarifies expectations for GCP-compliant eHR implementations, including audit trails and the ability for investigators to demonstrate oversight when eHR systems are used. The warning is intended to protect research competitiveness and improve patient recruitment access to advanced medicines.