Significant upheaval is underway in U.S. public health governance. Health Secretary Robert F. Kennedy Jr. controversially dismissed all 17 members of the CDC’s Advisory Committee on Immunization Practices (ACIP), provoking concerns over vaccine policy stability. Concurrently, over 300 NIH scientists issued the Bethesda Declaration protesting politicization of research funding and staff cuts under the Trump administration. These developments intersect with regulatory uncertainties affecting drug approvals and antiviral testing, prompting industry and government scrutiny over future policy direction and scientific independence.