Critical regulatory changes shape the future of biomedical research and drug safety reporting. The FDA initiated daily public dissemination of adverse event reports, enhancing pharmacovigilance transparency. NIH unveiled a comprehensive plan to enforce President Trump's directives for standards in reproducibility, transparency, and ethical conduct in science, with a focus on genomics and interdisciplinary collaboration. The Delhi High Court mandated the immediate blocking of shadow libraries Sci-Hub and Libgen in India due to copyright infringement concerns, sparking debate on access to scientific literature.