FDA efforts to reduce animal testing were reaffirmed by Commissioner Marty Makary, emphasizing streamlined drug development. Meanwhile, a federal lawsuit challenges recent federal changes to COVID-19 vaccine recommendations for pregnant women and children under HHS Secretary RFK Jr., citing public health concerns. The Supreme Court halted a lower court order restricting RFK Jr.'s reorganization plans for the HHS, enabling continuation of agency downsizing. These policy and legal movements indicate shifting regulatory landscapes impacting biotech innovation and vaccine policy.