A study using patient-derived stem-cell teratomas reported living test-bed models for Duchenne gene editing, where both gene-corrected cell transplants and lipid nanoparticle base editing restored dystrophin with effects dependent on muscle maturation. In tissue engineering, researchers built vascularized, immune-integrated human skin assembloids that model atopic dermatitis-like inflammation and responded to approved drugs, establishing a platform relevant for therapeutic screening. For cancer rehabilitation-adjacent regeneration, a study reported that a dental pulp stem cell secretome reduced oxidative stress and neuroinflammation and improved motor and cognitive outcomes in ischemic stroke mice. Together, these papers advance translational readiness by improving model fidelity—patient-derived, immune-aware, and drug-responsive—rather than relying on abstract in vitro systems alone.