Waseda University researchers unveiled a nanotube membrane-based injector designed to transfer cytoplasmic contents between living cell populations with high viability. Published in Small Science, the platform uses a thin gold membrane with vertically aligned nanotubes; by tuning internal air pressure, the system “sucks up” material from donor cells and flushes it into recipients. The team reported cell viability around 95% under optimized parameters and cytoplasmic transfer efficiency above 90%. They also demonstrated delivery of intact mitochondria by labeling donor mitochondria and tracking their presence in recipient cells via confocal microscopy. The advance targets a long-standing bottleneck in cell engineering—controlled intracellular material transfer without detergents, enzymes, or damaging physical disruption—potentially enabling improved research workflows in mitochondrial biology and beyond.
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