University of Pittsburgh-led researchers reported blood concentration cutoffs for brain injury proteins GFAP and UCH-L1 that could help emergency clinicians identify intracranial pathology missed by CT. The study focused on clinical blood biomarkers intended to improve detection in traumatic brain injury settings. If validated prospectively, the work could influence triage workflows where CT availability and sensitivity constraints leave a gap for certain patients. It also strengthens the broader case for multimodal assessment in acute neurology. The reported contribution is centered on clinically actionable thresholds derived from measured concentrations rather than imaging-only strategies.