An open-source automated genomic reanalysis tool called Talos delivered 241 rare-disease diagnoses in a recent Nature Medicine study after being tested on 4,735 previously unsolved patients’ genomes. The software was developed by Australia’s Centre for Population Genomics in collaboration with Australian Genomics, the Broad Institute, and Microsoft Research. More than half of the diagnoses came from newly discovered gene–variant–disease relationships identified after the original sequences were analyzed—addressing a key gap where patients often need reanalysis only when clinicians and families reinitiate workups. Because Talos is open source, institutions can tune sensitivity and specificity, but the paper’s authors emphasized that labs still need manual review of positives to maintain high clinical specificity.