A PUPER perfusion device called “Mother” preserved a donated human uterus outside the body for the first time, keeping the organ alive for one day using modified blood in a perfusion system designed to mimic living physiology. The approach, developed by researchers at the Carlos Simon Foundation in Valencia, Spain, has not yet been published. The team’s near-term goal is to extend survival long enough to observe a full menstrual cycle, enabling deeper study of implantation—the early step in pregnancy—particularly relevant to IVF failure mechanisms. Researchers also aim to study how embryos burrow into the uterine lining. For biotech and translational science, the work could become a platform for studying reproductive pathology and potentially for development of next-generation IVF interventions, pending peer-reviewed validation of perfusion viability and longer-term functional outcomes.