Researchers developed a method to quickly generate vascular organoids from human induced pluripotent stem cells by simultaneous activation of transcription factors ETV2 and NKX3.1. This technique produces functional blood vessels comprising endothelial and mural cells within five days, with organoids capable of connecting to host vasculature in vivo. The approach holds promise for tissue engineering and modeling vascular diseases, offering control over cellular differentiation to facilitate therapeutic applications.