A new method enables swift generation of functional vascular organoids from human stem cells by simultaneous activation of endothelial and mural lineage transcription factors. Published in Cell Stem Cell, the approach achieves coordinated differentiation and self-assembly of vascular networks within days, offering precise control of vessel formation. Organoids demonstrated in vivo perfusion and therapeutic potential for ischemia and transplantation models, marking a pivotal advance in vascular biology and regenerative medicine platforms.