A programmable smartphone-integrated microfluidic platform reports attomolar sensitivity and accuracy above 95% across molecular and protein assays, reframing point-of-care diagnostics beyond single analyte tests. The system is positioned for “multidimensional health profiling,” where multiple biomarkers can be assessed from small samples in a decentralized workflow. For diagnostics companies and translational teams, the reported performance targets a long-standing barrier: combining analytical sensitivity with practical hardware constraints suitable for clinic or home settings.