A new computational platform rapidly generates complex vasculature trees at organ scale within minutes, a 230-fold speed increase over previous methods. Developed by Sexton and colleagues, it optimizes vascular geometries for 3D bioprinting and perfusion of tissue constructs, significantly improving cell viability. Over 200 anatomical models were designed and tested in bioreactors, addressing a critical bottleneck in engineering functional tissues and organs for regenerative medicine applications.