Researchers from Boston Children’s Hospital and collaborators have developed an accelerated method to generate vascular organoids from human induced pluripotent stem cells (iPSCs) by simultaneously activating two transcription factors, ETV2 and NKX3.1. This approach yields self-assembling microvascular networks comprising endothelial and mural cells within five days. The organoids demonstrate functionality with host integration in vivo, facilitating potential applications in tissue engineering and regenerative medicine. The study was published in Cell Stem Cell.