ASTRO updated its radiation therapy guidance for adult pancreatic cancer, replacing the 2019 version and publishing the revised guideline in Practical Radiation Oncology. The change is expected to influence planning choices at a point when survival outcomes remain poor and radiation strategies are closely tied to multimodality sequencing. For clinicians and trial designers, the guideline update serves as a near-term reference point for standard-of-care comparators, reinforcing how practice-changing consensus documents can shift which regimens are considered guideline-concordant in future studies.