A JAMA study reports that the YEARS diagnostic algorithm performs comparably to standard computed tomographic pulmonary angiography (CTPA) for diagnosing pulmonary embolism in cancer patients, while reducing the need for invasive imaging. The research frames YEARS as a frontline tool that can safely triage which patients require CTPA. The YEARS approach uses clinical criteria and D-dimer thresholds to guide whether CTPA is necessary. In the study, investigators found the algorithm’s efficacy matched CTPA in diagnostic performance, with imaging requirements falling in more than one-fifth of patients. For oncology care pathways, the reported reduction in CTPA could lower radiation exposure, contrast risk, and downstream utilization pressures—particularly relevant in populations already facing high diagnostic burdens. The findings support algorithm-based diagnostic stewardship in a high-risk setting.