The Chan Zuckerberg Initiative’s Biohub released the ESM Atlas, an open (or openly available) resource comprising more than one billion predicted protein structures and billions of sequences generated with ESMFold2. The release expands coverage beyond the AlphaFold database by hundreds of millions of entries. Biohub said ESMFold2 outperforms other methods for predicting protein complex structures and that metagenomic sequences—previously underrepresented—are included. The atlas is positioned as a substrate for discovery of new biology, including antibody and protein design using predicted binding interactions. For antibody and therapeutic protein developers, the release accelerates in silico screening inputs while intensifying competition among open-source and proprietary protein-structure platforms.