Sartorius researchers described a multi-controller nonlinear model predictive control system designed for continuous CHO perfusion. In experiments supported by digital twin modeling, the approach increased production by 68% and maintained viable cell density at or above 95%, while enabling seamless transitions between stability and economic optimization objectives. On the manufacturing cost front, MIT researchers outlined an electrokinetic cleaning approach to improve media recycling for perfusion. The method uses electric fields to separate spent media into nutrient-rich harvest streams and charged waste streams, with reported recovery of 87.5% of spent volume while aiming to avoid productivity losses that can occur with direct recycling. Together, the advances point to bioprocess control and downstream process design as practical levers for scaling continuous manufacturing and making perfusion economically viable at larger output volumes.