Researchers at the Broad Institute and Jackson Laboratory have demonstrated successful use of prime editing to correct five distinct genetic mutations causing alternating hemiplegia of childhood (AHC) in mouse models. The treatment reduced severity and frequency of paralysis and seizures and extended survival more than twofold. This study marks the first application of prime editing to neurological disease in animals and outlines a scalable framework for parallel correction of multiple mutations in rare diseases. The findings, published in Cell, highlight promising therapeutic avenues for genetically defined neurological disorders traditionally considered untreatable.