Two breakthrough reports expanded prime editing’s therapeutic toolbox. David Liu’s Broad Institute team described a prime editing‑mediated readthrough approach (PERT) that converts an endogenous tRNA into a suppressor RNA to address diverse nonsense mutations without editing the mutated gene directly. Separately, a Nature paper demonstrated prime‑editing installation of suppressor tRNAs and showed that optimized suppressor tRNAs improve rescue of premature stop codons in multiple cellular and animal disease models. Both studies aim to create broadly applicable, one‑agent treatments for classes of genetic disorders and report limited off‑target effects in the reported datasets.