Scientists published Prime‑Editing‑Based Inversion with Enhanced Performance (PIE), a technique that enables efficient, large‑scale inversion of genomic DNA at chromosomal scale in mammalian cells. PIE adapts prime editing to perform directed inversions with improved efficiency and precision compared with prior approaches. The method provides a new tool to model structural variants and study inversion biology; authors highlight potential uses in functional genomics and disease modeling while noting translational use will require careful off‑target and safety characterization.