Two Nature Biotechnology papers report that transplantation of human embryonic stem cell‑derived spinal neural stem cells produced extensive restoration of forelimb function in rhesus monkeys with cervical spinal cord injury. The studies showed functional recovery in a substantial fraction of treated animals and documented safety and integration metrics that support clinical translation. Authors detailed electrophysiology, behavioral outcomes, and histological integration, with one paper reporting restored hand function in 53% of trials. The work underscores steps toward IND‑enabling packages for neural stem cell therapies targeting cervical injuries and highlights scalable differentiation and delivery protocols. Investigators and translational teams emphasized that primate recovery data bridge critical preclinical gaps and will inform dosing, delivery routes, and safety monitoring for planned human trials. Regulatory and manufacturing workstreams will need to address cell sourcing, batch release criteria, and long‑term monitoring.