A multicenter study involving 4,801 patients has revealed that preoperative body mass index (BMI) plays a critical role in postoperative outcomes for individuals undergoing cardiac surgery due to infective endocarditis. The research, published in the International Journal of Obesity, uncovers complex associations between BMI categories and surgical risks, supporting the integration of nutritional assessment in preoperative evaluation. These findings may influence clinical guidelines for managing infective endocarditis cases.