Groundbreaking work published in Pediatric Research detailed how antenatal inflammation contributes to late pulmonary hypertension in bronchopulmonary dysplasia (BPD), highlighting early inflammatory insults as pivotal in chronic lung vascular remodeling. Complementary studies investigated adults born with very low birth weight, tracing pulmonary function decline through mid-adulthood and offering key insights into long-term respiratory vulnerability rooted in neonatal adversity. These findings refine understanding of lung disease developmental origins and have implications for early intervention strategies.