Researchers demonstrated a scalable workflow to generate thousands of human kidney organoids and integrate them into porcine kidneys during ex vivo normothermic perfusion. Teams at the Institute for Bioengineering of Catalonia and international collaborators reported successful infusion and short‑term integration in pigs, publishing the results in Nature Biomedical Engineering. The method couples controlled, high‑throughput organoid differentiation with established organ perfusion systems, enabling real‑time evaluation of organoid viability and engraftment in a large‑animal setting. The investigators showed uniform organoid production and monitored function after insertion into perfused porcine kidneys. Authors propose the platform could accelerate preclinical testing of organoid therapies, provide production scale for translational studies, and inform protocols for future human applications. They caution that long‑term function, immune compatibility, and regulatory pathways will determine clinical feasibility.