Akbari and colleagues reported that co‑encapsulating cisplatin with the natural compound silibinin in biodegradable PLGA nanoparticles improved tumor uptake and anti‑cancer efficacy in preclinical cervical cancer models. The study showed enhanced cytotoxicity and tumor growth suppression versus free drug, suggesting improved delivery and potential dose‑sparing benefits. The formulation could inform combination chemo‑delivery strategies and move toward translational evaluation. Clarification: PLGA is an FDA‑approved biodegradable polymer frequently used for controlled drug delivery.