Researchers at Harvard’s Wyss Institute have developed a novel stem cell differentiation protocol that induces meiosis directly from induced pluripotent stem cells (iPSCs), bypassing precursor stages that previously hindered modeling of human gametogenesis. This advancement enables deeper investigation into infertility causes and drug development for reproductive disorders. Renowned geneticist George Church underscores its potential to generate healthy gametes in vitro, addressing the global infertility crisis affecting one in six individuals.